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The IKK Inhibitor Bay 11-7082 Induces Cell Death Independent from Inhibition of Activation of NFκB Transcription Factors
Multiple myeloma (MM) displays an NFκB activity-related gene expression signature and about 20% of primary MM samples harbor genetic alterations conducive to intrinsic NFκB signaling activation. The relevance of blocking the classical versus the alternative NFκB signaling pathway and the molecular e...
Autores principales: | Rauert-Wunderlich, Hilka, Siegmund, Daniela, Maier, Eduard, Giner, Tina, Bargou, Ralf C., Wajant, Harald, Stühmer, Thorsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603909/ https://www.ncbi.nlm.nih.gov/pubmed/23527154 http://dx.doi.org/10.1371/journal.pone.0059292 |
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