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G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

We recently identified a novel GPCR-dependent pathway for regulation of cardiac hypertrophy that depends on Golgi phosphatidylinositol 4-phosphate (PI4P) hydrolysis by a specific isoform of phospholipase C (PLC), PLCε, at the nuclear envelope. How stimuli are transmitted from cell surface GPCRs to a...

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Detalles Bibliográficos
Autores principales:	Malik, S., deRubio, R. G., Trembley, M., Irannejad, R., Wedegaertner, P. B., Smrcka, A. V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357516/ https://www.ncbi.nlm.nih.gov/pubmed/25609085 http://dx.doi.org/10.1091/mbc.E14-10-1476

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