The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds

An mRNA gene therapy represents a potentially promising therapeutic for curing inflammatory diseases. The transient nature of the gene expression of mRNA would be expected to be beneficial for avoiding undesired side effects. Since the mRNA is a vulnerable molecule, a development of a carrier that c...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiroki, Watanabe, Ayaka, Konishi, Manami, Nakai, Yuta, Yoshioka, Hiroki, Ohkawara, Tatsuya, Takeda, Hiroshi, Harashima, Hideyoshi, Akita, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280607/
https://www.ncbi.nlm.nih.gov/pubmed/30555953
http://dx.doi.org/10.1016/j.heliyon.2018.e00959

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