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Structure-guided design of a high-affinity ligand for a riboswitch
We have designed structure-based ligands for the guanidine-II riboswitch that bind with enhanced affinity, exploiting the twin binding sites created by loop–loop interaction. We synthesized diguanidine species, comprising two guanidino groups covalently connected by C(n) linkers where n = 4 or 5. Ca...
Autores principales: | Huang, Lin, Wang, Jia, Wilson, Timothy J., Lilley, David M.J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426286/ https://www.ncbi.nlm.nih.gov/pubmed/30609994 http://dx.doi.org/10.1261/rna.069567.118 |
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