Structure-guided design of a high-affinity ligand for a riboswitch

We have designed structure-based ligands for the guanidine-II riboswitch that bind with enhanced affinity, exploiting the twin binding sites created by loop–loop interaction. We synthesized diguanidine species, comprising two guanidino groups covalently connected by C(n) linkers where n = 4 or 5. Ca...

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Detalles Bibliográficos
Autores principales: Huang, Lin, Wang, Jia, Wilson, Timothy J., Lilley, David M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426286/
https://www.ncbi.nlm.nih.gov/pubmed/30609994
http://dx.doi.org/10.1261/rna.069567.118

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