Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordinate proliferation and differentiation during early neural de...

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Detalles Bibliográficos
Autores principales: Raj, Nisha, McEachin, Zachary T., Harousseau, William, Zhou, Ying, Zhang, Feiran, Merritt-Garza, Megan E., Taliaferro, J. Matthew, Kalinowska, Magdalena, Marro, Samuele G., Hales, Chadwick M., Berry-Kravis, Elizabeth, Wolf-Ochoa, Marisol W., Martinez-Cerdeño, Veronica, Wernig, Marius, Chen, Lu, Klann, Eric, Warren, Stephen T., Jin, Peng, Wen, Zhexing, Bassell, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133829/
https://www.ncbi.nlm.nih.gov/pubmed/33852833
http://dx.doi.org/10.1016/j.celrep.2021.108991

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