Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

Pregnancy-Associated Plasma Protein A isoforms, PAPP-A and PAPP-A2, are metalloproteases that cleave insulin-like growth factor binding proteins (IGFBPs) to modulate insulin-like growth factor signaling. The structures of homodimeric PAPP-A in complex with IGFBP5 anchor peptide, and inhibitor protei...

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Detalles Bibliográficos
Autores principales: Sridar, Janani, Mafi, Amirhossein, Judge, Russell A., Xu, Jun, Kong, Kailyn A., Wang, John C. K., Stoll, Vincent S., Koukos, Georgios, Simon, Reyna J., Eaton, Dan, Bratkowski, Matthew, Hao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613257/
https://www.ncbi.nlm.nih.gov/pubmed/37898658
http://dx.doi.org/10.1038/s42004-023-01032-y

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