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Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA-damage-inducing therapeutics. Here we identify an HR-defect (HRD) gene signature, which can be used to functionally assess HR repair status without interrogating individual gene...
Autores principales: | Peng, Guang, Lin, Curtis Chun-Jen, Mo, Wei, Dai, Hui, Park, Yun-Yong, Kim, Soo-Mi, Peng, Yang, Mo, Qianxing, Siwko, Stefan, Hu, Ruozhen, Lee, Ju-Seog, Hennessy, Bryan, Hanash, Samir, Mills, Gordon B., Lin, Shiaw-Yih |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017859/ https://www.ncbi.nlm.nih.gov/pubmed/24553445 http://dx.doi.org/10.1038/ncomms4361 |
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