Increasing pentose phosphate pathway flux enhances recombinant protein production in Pichia pastoris

Production of heterologous proteins in Pichia pastoris (syn. Komagataella sp.) has been shown to exert a metabolic burden on the host metabolism. This burden is associated with metabolite drain, which redirects nucleotides and amino acids from primary metabolism. On the other hand, recombinant prote...

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Detalles Bibliográficos
Autores principales: Nocon, Justyna, Steiger, Matthias, Mairinger, Teresa, Hohlweg, Jonas, Rußmayer, Hannes, Hann, Stephan, Gasser, Brigitte, Mattanovich, Diethard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Applied Microbial and Cell Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909809/
https://www.ncbi.nlm.nih.gov/pubmed/27020289
http://dx.doi.org/10.1007/s00253-016-7363-5

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