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Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks
Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases including cancer. Recent work has revealed that the poorly studied AGC kinase family member, SGK3, promotes resistance to cancer therapies that target the Class 1 PI3K pathway, by substituting for loss of...
Autores principales: | Malik, Nazma, Macartney, Thomas, Hornberger, Annika, Anderson, Karen E., Tovell, Hannah, Prescott, Alan R., Alessi, Dario R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748840/ https://www.ncbi.nlm.nih.gov/pubmed/29150437 http://dx.doi.org/10.1042/BCJ20170650 |
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