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A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes
BACKGROUND: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to improve our...
Autores principales: | Youn, Ahrim, Kim, Kyung In, Rabadan, Raul, Tycko, Benjamin, Shen, Yufeng, Wang, Shuang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218985/ https://www.ncbi.nlm.nih.gov/pubmed/30400878 http://dx.doi.org/10.1186/s12920-018-0425-z |
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