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Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates...
Autores principales: | Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C. A., Beveridge, A. J., Brown, H., Hume, D. A., Harris, S. E., Deary, I. J., Tenesa, A., Prendergast, J. G. D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969137/ https://www.ncbi.nlm.nih.gov/pubmed/31953380 http://dx.doi.org/10.1038/s41467-019-13762-6 |
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