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Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
Fragile X syndrome (FXS) is the most common genetic form of intellectual disability caused by a CGG repeat expansion in the 5′‐UTR of the Fragile X mental retardation gene FMR1, triggering epigenetic silencing and the subsequent absence of the protein, FMRP. Reactivation of FMR1 represents an attrac...
Autores principales: | Graef, John D., Wu, Hao, Ng, Carrie, Sun, Chicheng, Villegas, Vivian, Qadir, Deena, Jesseman, Kimberly, Warren, Stephen T., Jaenisch, Rudolf, Cacace, Angela, Wallace, Owen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318714/ https://www.ncbi.nlm.nih.gov/pubmed/31880363 http://dx.doi.org/10.1111/ejn.14660 |
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