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Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing
BACKGROUND: Circulating cell-free DNA (cfDNA) methylation has been demonstrated to be a promising approach for non-invasive cancer diagnosis. However, the high cost of whole genome bisulfite sequencing (WGBS) hinders the clinical implementation of a methylation-based cfDNA early detection biomarker....
Autores principales: | Zhang, Haikun, Dong, Peiling, Guo, Shicheng, Tao, Chengcheng, Chen, Wei, Zhao, Wenmin, Wang, Jiakang, Cheung, Ramsey, Villanueva, Augusto, Fan, Jian, Ding, Huiguo, Schrodi, Steven J., Zhang, Dake, Zeng, Changqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397586/ https://www.ncbi.nlm.nih.gov/pubmed/32741373 http://dx.doi.org/10.1186/s12916-020-01667-x |
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