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Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that could respectively cause BRAF V600K and V600E oncogenic mutations. The mutagenic bypass mechanism past these at...
Autores principales: | Vandenberg, Brittany N., Laughery, Marian F., Cordero, Cameron, Plummer, Dalton, Mitchell, Debra, Kreyenhagen, Jordan, Albaqshi, Fatimah, Brown, Alexander J., Mieczkowski, Piotr A., Wyrick, John J., Roberts, Steven A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10160025/ https://www.ncbi.nlm.nih.gov/pubmed/37142570 http://dx.doi.org/10.1038/s41467-023-38255-5 |
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