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A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex
As a centerpiece of antigen processing, the ATP-binding cassette transporter associated with antigen processing (TAP) became a main target for viral immune evasion. The herpesviral ICP47 inhibits TAP function, thereby suppressing an adaptive immune response. Here, we report on a thermostable ICP47-T...
Autores principales: | Herbring, Valentina, Bäucker, Anja, Trowitzsch, Simon, Tampé, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109273/ https://www.ncbi.nlm.nih.gov/pubmed/27845362 http://dx.doi.org/10.1038/srep36907 |
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