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Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity
Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activators. High CD...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764959/ https://www.ncbi.nlm.nih.gov/pubmed/31562298 http://dx.doi.org/10.1038/s41467-019-12307-1 |