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New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity

New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alkoxyalkyl esters, amino acid phosphoramidates and/or tyrosine. The activity...

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Detalles Bibliográficos
Autores principales:	Krečmerová, Marcela, Dračínský, Martin, Snoeck, Robert, Balzarini, Jan, Pomeisl, Karel, Andrei, Graciela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126465/ https://www.ncbi.nlm.nih.gov/pubmed/28757102 http://dx.doi.org/10.1016/j.bmc.2017.06.046

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