Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Misfolded Cu, Zn-superoxide dismutase (SOD1) has been linked to both familial and sporadic ALS. SOD1 fibrils formed in vitro share toxic properties with ALS inclusions. Here we produced cytotoxic amyloid fibrils from full-length apo...

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Detalles Bibliográficos
Autores principales: Wang, Li-Qiang, Ma, Yeyang, Yuan, Han-Ye, Zhao, Kun, Zhang, Mu-Ya, Wang, Qiang, Huang, Xi, Xu, Wen-Chang, Dai, Bin, Chen, Jie, Li, Dan, Zhang, Delin, Wang, Zhengzhi, Zou, Liangyu, Yin, Ping, Liu, Cong, Liang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205981/
https://www.ncbi.nlm.nih.gov/pubmed/35715417
http://dx.doi.org/10.1038/s41467-022-31240-4

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