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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

Tudor-interacting repair regulator (TIRR) is an RNA-binding protein and a negative regulator of the DNA-repair factor p53-binding protein 1 (53BP1). In non-damage conditions, TIRR is bound to 53BP1. After DNA damage, TIRR and 53BP1 dissociate, and 53BP1 binds the chromatin at the double-strand break...

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Detalles Bibliográficos
Autores principales:	Ketley, Ruth F., Battistini, Federica, Alagia, Adele, Mondielli, Clémence, Iehl, Florence, Balikçi, Esra, Huber, Kilian V.M., Orozco, Modesto, Gullerova, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638026/ https://www.ncbi.nlm.nih.gov/pubmed/36288694 http://dx.doi.org/10.1016/j.celrep.2022.111526

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