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Multivalent interactions essential for lentiviral integrase function
A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into a host cell genome. Reconstitution of the intasome from the maedi-visna virus (MVV), an ovine lentivirus, revealed a large assembly containing sixteen IN subunits(1). H...
Autores principales: | Ballandras-Colas, Allison, Chivukula, Vidya, Gruszka, Dominika T., Shan, Zelin, Singh, Parmit K., Pye, Valerie E., McLean, Rebecca K., Bedwell, Gregory J., Li, Wen, Nans, Andrea, Cook, Nicola J., Fadel, Hind J., Poeschla, Eric M., Griffiths, David J., Vargas, Javier, Taylor, Ian A., Lyumkis, Dmitry, Yardimci, Hasan, Engelman, Alan N., Cherepanov, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065133/ https://www.ncbi.nlm.nih.gov/pubmed/35504909 http://dx.doi.org/10.1038/s41467-022-29928-8 |
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