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Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases
Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase–quinolone complexes. A careful statistical analysis of...
Autores principales: | Richter, Sara N., Giaretta, Giulia, Comuzzi, Valentina, Leo, Elisabetta, Mitchenall, Lesley A., Fisher, L. Mark, Maxwell, Anthony, Palumbo, Manlio |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094056/ https://www.ncbi.nlm.nih.gov/pubmed/17766248 http://dx.doi.org/10.1093/nar/gkm653 |
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