Cargando…

Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is an escalating medical problem worldwide. A nonsynonymous single nucleotide polymorphism rs738409 (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yiling, Xing, Chao, Tian, Zhong, Ku, Hung-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523076/ https://www.ncbi.nlm.nih.gov/pubmed/23176674 http://dx.doi.org/10.1186/1471-2350-13-113

Ejemplares similares

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
por: Smagris, Eriks, et al.
Publicado: (2015)

Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B
por: Hsueh, Rei-Chi, et al.
Publicado: (2022)

Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C
por: De Nicola, Stella, et al.
Publicado: (2014)

A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis
por: Rosendahl, Jonas, et al.
Publicado: (2012)

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction
por: Gou, Yusong, et al.
Publicado: (2023)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes
por: Mancina, Rosellina Margherita, et al.
Publicado: (2015)

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
por: BasuRay, Soumik, et al.
Publicado: (2017)

PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
por: Huang, Chung-Feng, et al.
Publicado: (2015)

PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma
por: Valenti, Luca, et al.
Publicado: (2013)

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL
por: Witzel, Hagen Roland, et al.
Publicado: (2022)

Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation
por: Geng, Ning, et al.
Publicado: (2015)

Clinically silent LINE 1 insertion in the PNPLA3 gene may impede genotyping of the p.I148M variant
por: Leníček, Martin, et al.
Publicado: (2021)

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
por: Kim, Hyun-seok, et al.
Publicado: (2022)

PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients
por: Nakaoka, Kazunori, et al.
Publicado: (2015)

PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease
por: BasuRay, Soumik
Publicado: (2019)

PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells
por: Bruschi, Francesca Virginia, et al.
Publicado: (2019)

Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M
por: Rausch, Vanessa, et al.
Publicado: (2016)

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
por: Cherubini, Alessandro, et al.
Publicado: (2023)

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls
por: Valenti, Luca, et al.
Publicado: (2012)

PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells
por: Bruschi, Francesca Virginia, et al.
Publicado: (2020)

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
por: He, Shaoqing, et al.
Publicado: (2010)

PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection
por: Rembeck, Karolina, et al.
Publicado: (2012)

PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis
por: Burza, Maria Antonella, et al.
Publicado: (2014)

Impact of PNPLA3 and IFNL3 polymorphisms on hepatic steatosis in Asian patients with chronic hepatitis C
por: Huang, Chao-Min, et al.
Publicado: (2017)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M
por: Tardelli, Matteo, et al.
Publicado: (2017)

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
por: Sherman, David J., et al.
Publicado: (2023)

The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2014)

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
por: BasuRay, Soumik, et al.
Publicado: (2019)

Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis
por: Seeßle, Jessica, et al.
Publicado: (2020)

The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value
por: Paolini, Erika, et al.
Publicado: (2023)

Erratum to: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2016)

The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism
por: Chen, Lizhen, et al.
Publicado: (2017)

Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3 ( I148M ) risk allele
por: Kirchmeyer, Mélanie, et al.
Publicado: (2023)

Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant
por: Palmer, Colin N. A., et al.
Publicado: (2012)

The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort
por: Krawczyk, Marcin, et al.
Publicado: (2015)

PNPLA3 I148M mediates the regulatory effect of NF‐kB on inflammation in PA‐treated HepG2 cells
por: Yuan, Shuhua, et al.
Publicado: (2019)

Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China
por: Zhang, Yuexin, et al.
Publicado: (2014)

Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
por: Morrill, Kristin E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oliuefifghtb4v44u4nb28t5bc