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Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity
Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-induced cervical tumorigenesis and several neurodevelopmental disorders. Yet the structural underpinnings of activity and specificity in this crucial ligase are incompletely understood. Here, we unrave...
Autores principales: | Ries, Lena K., Sander, Bodo, Deol, Kirandeep K., Letzelter, Marie-Annick, Strieter, Eric Robert, Lorenz, Sonja |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463701/ https://www.ncbi.nlm.nih.gov/pubmed/30737286 http://dx.doi.org/10.1074/jbc.RA118.007014 |
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