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Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
Signal transduction from the T cell receptor (TCR) is crucial for T cell–mediated immune responses and, when deregulated, also contributes to the development of autoimmunity. How TCR signaling is regulated is incompletely understood. In this study, we demonstrate a ubiquitin-dependent mechanism in w...
Autores principales: | Hu, Hongbo, Wang, Hui, Xiao, Yichuan, Jin, Jin, Chang, Jae-Hoon, Zou, Qiang, Xie, Xiaoping, Cheng, Xuhong, Sun, Shao-Cong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813674/ https://www.ncbi.nlm.nih.gov/pubmed/26903241 http://dx.doi.org/10.1084/jem.20151426 |
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