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Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking
Cyclotides or cyclic cystine-knot peptides have emerged as a promising class of pharmacological ligands that modulate protein function. Interestingly, very few cyclotides have been shown to enter into cells. Yet, it remains unknown whether backbone cyclization is required for their cellular internal...
Autores principales: | Gao, Xinxin, Stanger, Karen, Kaluarachchi, Harini, Maurer, Till, Ciepla, Paulina, Chalouni, Cecile, Franke, Yvonne, Hannoush, Rami N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062073/ https://www.ncbi.nlm.nih.gov/pubmed/27734922 http://dx.doi.org/10.1038/srep35179 |
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