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GRB2 enforces homology-directed repair initiation by MRE11
DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here, we found that GRB2, crucial to timely proliferative RAS/MAPK pathway activation, unexpectedly forms a biophysically validated GRB2-MRE11 (GM) comple...
Autores principales: | Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G., Jones, Darin E., Wang, Bin, Tainer, John A., Ahmed, Zamal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336959/ https://www.ncbi.nlm.nih.gov/pubmed/34348893 http://dx.doi.org/10.1126/sciadv.abe9254 |
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