Cargando…
Molecular Modeling Study on Tunnel Behavior in Different Histone Deacetylase Isoforms
Histone deacetylases (HDACs) have emerged as effective therapeutic targets in the treatment of various diseases including cancers as these enzymes directly involved in the epigenetic regulation of genes. However the development of isoform-selective HDAC inhibitors has been a challenge till date sinc...
Autores principales: | Thangapandian, Sundarapandian, John, Shalini, Lee, Yuno, Arulalapperumal, Venkatesh, Lee, Keun Woo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510210/ https://www.ncbi.nlm.nih.gov/pubmed/23209570 http://dx.doi.org/10.1371/journal.pone.0049327 |
Ejemplares similares
-
Dynamic Structure-Based Pharmacophore Model Development: A New and Effective Addition in the Histone Deacetylase 8 (HDAC8) Inhibitor Discovery
por: Thangapandian, Sundarapandian, et al.
Publicado: (2011) -
Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
por: John, Shalini, et al.
Publicado: (2011) -
Molecular Dynamics Simulation Study and Hybrid Pharmacophore Model Development in Human LTA4H Inhibitor Design
por: Thangapandian, Sundarapandian, et al.
Publicado: (2012) -
Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations
por: Thangapandian, Sundarapandian, et al.
Publicado: (2012) -
Molecular Dynamics Simulations of Sonic Hedgehog-Receptor and Inhibitor Complexes and Their Applications for Potential Anticancer Agent Discovery
por: Hwang, Swan, et al.
Publicado: (2013)