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PCNA promotes processive DNA end resection by Exo1
Exo1-mediated resection of DNA double-strand break ends generates 3′ single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the...
Autores principales: | Chen, Xiaoqing, Paudyal, Sharad C., Chin, Re-I, You, Zhongsheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814391/ https://www.ncbi.nlm.nih.gov/pubmed/23939618 http://dx.doi.org/10.1093/nar/gkt672 |
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