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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains
The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease–related leucine-rich repeat kinase 2 (LRRK2). Using hydrogen–deuterium exchange mass spectrometry (HDX-MS) and molecular dynamics (MD) simulations, we generated a comprehensive dynamic alloste...
Autores principales: | Weng, Jui-Hung, Aoto, Phillip C., Lorenz, Robin, Wu, Jian, Schmidt, Sven H., Manschwetus, Jascha T., Kaila-Sharma, Pallavi, Silletti, Steve, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863276/ https://www.ncbi.nlm.nih.gov/pubmed/35192607 http://dx.doi.org/10.1371/journal.pbio.3001427 |
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