Cargando…
Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...
Autores principales: | Cavadas, Miguel, Oikonomidi, Ioanna, Gaspar, Catarina J., Burbridge, Emma, Badenes, Marina, Félix, Inês, Bolado, Alfonso, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Domingos, Pedro M., von Kriegsheim, Alex, Adrain, Colin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656746/ https://www.ncbi.nlm.nih.gov/pubmed/29045841 http://dx.doi.org/10.1016/j.celrep.2017.09.074 |
Ejemplares similares
-
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
por: Oikonomidi, Ioanna, et al.
Publicado: (2018) -
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
por: Badenes, Marina, et al.
Publicado: (2019) -
Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
por: Babendreyer, Aaron, et al.
Publicado: (2020) -
Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution
por: Calligaris, Matteo, et al.
Publicado: (2021) -
Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways
por: Xu, Qin, et al.
Publicado: (2020)