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New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was assessed. Compound 16 was the most cytotoxic and To...
Autores principales: | Gaber, Ahmed A., Sobhy, Mohamed, Turky, Abdallah, Eldehna, Wagdy M., El-Sebaey, Samiha A., El-Metwally, Souad A., El-Naggar, Abeer M., Ibrahim, Ibrahim M., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886266/ https://www.ncbi.nlm.nih.gov/pubmed/36716311 http://dx.doi.org/10.1371/journal.pone.0274081 |
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