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Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening
The primate-specific brain voltage-gated potassium channel isoform Kv11.1-3.1 has been identified as a novel therapeutic target for the treatment of schizophrenia. While this ether-a-go-go related K( + )channel has shown clinical relevance, drug discovery efforts have been hampered due to low and in...
Autores principales: | Calcaterra, Nicholas E., Hoeppner, Daniel J., Wei, Huijun, Jaffe, Andrew E., Maher, Brady J., Barrow, James C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754628/ https://www.ncbi.nlm.nih.gov/pubmed/26879421 http://dx.doi.org/10.1038/srep19976 |
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